We investigated how choline magnesium trisalicylate (CMT) helps alleviate bone pain in patients with metastatic cancer. In a carefully designed study involving 26 participants, we compared CMT against a placebo in a crossover format, measuring pain relief at multiple intervals after dosing.
While we observed a significant reduction in pain just one hour post-treatment with CMT, other comparisons showed improvements that didn't reach statistical significance. This suggested that CMT might assist in managing bone pain, potentially complementing traditional opioids, but overall effectiveness is still under exploration.
Read More
7
Pamidronate therapy reduces bone pain
New trends in the treatment of osteogenesis imperfecta type III - own experience.
We evaluated the effects of pamidronate therapy on children with osteogenesis imperfecta type III. Over the course of treatment, we saw reductions in bone pain, alongside a significant decrease in fracture incidence.
The therapy positively impacted children's daily activities and their overall mobility. Importantly, the treatment was found to be safe, although some patients experienced mild side effects like low calcium levels and a fever. Overall, our findings suggest that bisphosphonate therapy is beneficial for management in these young patients.
Read More
8
Calcium's role in bone pain unclear
In-depth clinical characterization of intravenous iron infusion-induced hypophosphatemic osteomalacia and its resolution.
We explored the impact of calcium treatment on bone pain in patients who developed osteomalacia, a condition linked to intravenous iron infusions. Our focus was on a group of 13 patients diagnosed with this condition, who experienced low phosphate levels due to excess fibroblast growth factor 23 (iFGF23) after receiving ferric carboxymaltose (FCM) infusions.
After halting the FCM infusions, these patients were given supportive treatment, which included phosphate, calcium, and active Vitamin D supplementation. We observed improvements in biochemical markers, including increased phosphate levels and reduced pain scores. However, it’s important to note that while calcium was part of the treatment regimen, we could not isolate its specific effects on bone pain from the other supportive measures used.
Ultimately, our findings highlight the importance of monitoring phosphate levels in patients receiving FCM, and stopping these infusions effectively addresses phosphate wasting. Although supportive treatment showed improvements in pain and bone density, the direct impact of calcium on bone pain remains unclear given the combination of treatments involved.
Read More
Most Useful Reviews
7.5
Pain relief achieved
7 people found this helpful
This effective drug has relieved irritability, improved my sleep, and eliminated muscle pain. I have experienced a fast recovery after workouts.
Read More
9
Heel pain reduced
6 people found this helpful
The heel pain has almost disappeared! I didn't initially associate this complex with my pain reduction, but after two weeks, my discomfort has diminished considerably, making it much easier to manage daily activities. I will order it again in citrate form next time!
Read More
9
Rapid pain cessation
4 people found this helpful
After suffering a severe leg injury while skiing, I was astonished by the rapid relief from pain after just one week of taking this calcium supplement. Although it may be coincidental, it has certainly brought me comfort. I also intend to try it on my elderly mother to assess its effects on her.
We explored the impact of calcium treatment on bone pain in patients who developed osteomalacia, a condition linked to intravenous iron infusions. Our focus was on a group of 13 patients diagnosed with this condition, who experienced low phosphate levels due to excess fibroblast growth factor 23 (iFGF23) after receiving ferric carboxymaltose (FCM) infusions.
After halting the FCM infusions, these patients were given supportive treatment, which included phosphate, calcium, and active Vitamin D supplementation. We observed improvements in biochemical markers, including increased phosphate levels and reduced pain scores. However, it’s important to note that while calcium was part of the treatment regimen, we could not isolate its specific effects on bone pain from the other supportive measures used.
Ultimately, our findings highlight the importance of monitoring phosphate levels in patients receiving FCM, and stopping these infusions effectively addresses phosphate wasting. Although supportive treatment showed improvements in pain and bone density, the direct impact of calcium on bone pain remains unclear given the combination of treatments involved.
Read More
7
Promising drug delivery for osteoporosis
Synthesis and characterization of novel denosumab/magnesium-based metal organic frameworks nanocomposite prepared by ultrasonic route as drug delivery system for the treatment of osteoporosis.
We developed a novel drug delivery system combining denosumab and magnesium within metal-organic frameworks to target osteoarthritis. The framework showed good potential for loaded drug release, delivering about 72% of denosumab in just 8 hours.
Additionally, it released magnesium ions, which are beneficial for bone formation. Our cytotoxicity tests demonstrated that the system is biocompatible and encourages cell growth over time. While our findings are promising for pain relief linked to osteoporosis, further studies are needed to confirm effectiveness in real-world scenarios.
Read More
7
Pamidronate therapy reduces bone pain
New trends in the treatment of osteogenesis imperfecta type III - own experience.
We evaluated the effects of pamidronate therapy on children with osteogenesis imperfecta type III. Over the course of treatment, we saw reductions in bone pain, alongside a significant decrease in fracture incidence.
The therapy positively impacted children's daily activities and their overall mobility. Importantly, the treatment was found to be safe, although some patients experienced mild side effects like low calcium levels and a fever. Overall, our findings suggest that bisphosphonate therapy is beneficial for management in these young patients.
Read More
7
CMT shows potential for pain relief
The efficacy of choline magnesium trisalicylate (CMT) in the management of metastatic bone pain: a pilot study.
We investigated how choline magnesium trisalicylate (CMT) helps alleviate bone pain in patients with metastatic cancer. In a carefully designed study involving 26 participants, we compared CMT against a placebo in a crossover format, measuring pain relief at multiple intervals after dosing.
While we observed a significant reduction in pain just one hour post-treatment with CMT, other comparisons showed improvements that didn't reach statistical significance. This suggested that CMT might assist in managing bone pain, potentially complementing traditional opioids, but overall effectiveness is still under exploration.
Read More
User Reviews
USERS' SCORE
Good
Based on 37 Reviews
8.2
All Reviews
Positive Reviews
Negative Reviews
7.5
Pain relief achieved
7 people found this helpful
This effective drug has relieved irritability, improved my sleep, and eliminated muscle pain. I have experienced a fast recovery after workouts.
Read More
9
Heel pain reduced
6 people found this helpful
The heel pain has almost disappeared! I didn't initially associate this complex with my pain reduction, but after two weeks, my discomfort has diminished considerably, making it much easier to manage daily activities. I will order it again in citrate form next time!
Read More
9
Rapid pain cessation
4 people found this helpful
After suffering a severe leg injury while skiing, I was astonished by the rapid relief from pain after just one week of taking this calcium supplement. Although it may be coincidental, it has certainly brought me comfort. I also intend to try it on my elderly mother to assess its effects on her.
Read More
9
No more dental pain
3 people found this helpful
I am pleased with my choice of calcium complex. The dosage and composition are excellent, and I have noticed a significant improvement in my condition. The pain from my teeth has completely vanished, allowing me to avoid immediate dental treatment.
Read More
9
Reduced joint pain
3 people found this helpful
Since winter, I've dealt with pain in my elbows and wrists. Prescribed osteoarthritis medication lowered my hemoglobin levels, but I opted for this complex instead. After a week of taking two tablets daily, I felt the difference—I could carry bags and clean with ease again. I also give this to my 10-year-old, but I wish the pills were smaller!
Bone pain is a discomfort or ache that originates within the bones themselves and can range from mild to severe. It is different from muscle or joint pain, as it directly affects the skeletal structure. Bone pain can be caused by a variety of factors, including injuries, medical conditions such as osteoarthritis or osteoporosis, infections, or tumors. Symptoms may vary depending on the underlying cause but often include a dull, penetrating ache that may worsen with movement or pressure.
If you're experiencing persistent bone pain, it’s essential to consult with a healthcare professional for a proper diagnosis and treatment plan. Imaging tests like X-rays, MRI, or CT scans may be utilized to determine the root cause of the pain. Treatment can vary widely, ranging from medications to alleviate pain and inflammation to physical therapy or, in some cases, surgical interventions. Understanding the underlying cause is crucial to effectively managing bone pain and ensuring the best path to recovery.
Calcium magnesium refers to a dietary supplement that combines two essential minerals, calcium and magnesium, which play critical roles in maintaining various bodily functions. Calcium is vital for building and maintaining strong bones and teeth, while magnesium supports muscle function, energy production, and the regulation of calcium levels in the body. Together, these minerals work synergistically to promote overall health, particularly in areas such as bone density, cardiovascular health, and muscle function.
Supplements that contain both calcium and magnesium can be particularly beneficial for individuals who may be deficient in these minerals due to dietary restrictions or health conditions. They are available in various forms, including tablets, capsules, and powders. When considering a calcium magnesium supplement, it's essential to choose a product with the right ratio of these minerals, as well as other supporting vitamins and minerals like vitamin D, which enhances calcium absorption. Always consult with a healthcare provider before starting any new supplement regimen to ensure it aligns with your health needs and goals.
Calcium and magnesium are essential minerals that play a crucial role in maintaining bone health. Calcium is the primary component of bone tissue, and ensuring adequate calcium intake is fundamental for the development and maintenance of strong bones. Magnesium also contributes to bone density and is involved in converting vitamin D to its active form, which aids in calcium absorption. If you experience bone pain, it could be due to a deficiency in these minerals, among other factors.
However, while ensuring proper levels of calcium and magnesium can potentially alleviate some bone-related discomfort, it is essential to approach the treatment of bone pain holistically. If you’re considering supplements, consult a healthcare professional for personalized advice. They might recommend lifestyle changes, dietary adjustments, or further assessments to determine the underlying cause of your bone pain, which could be related to osteoporosis, arthritis, or other medical conditions. In summary, while calcium and magnesium can support overall bone health, they shouldn't be solely relied upon to relieve bone pain without professional guidance.
Based on user reviews, many individuals report experiencing noticeable results in bone pain relief within a week to two weeks of taking the calcium and magnesium supplement. For instance, one user noted that their heel pain "almost disappeared" after just two weeks of use Read Review. Another mentioned being "astonished by the rapid relief from pain after just one week" following a severe injury Read Review. These quick improvements suggest that many users may experience similar results, particularly those with joint and muscle discomfort.
Others have highlighted progressive benefits, with some reporting significant improvements in bone health and pain symptoms after several months of consistent use. For example, one user indicated that after five months of using the product, all shoulder and knee pain had vanished Read Review. Overall, while many users report prompt relief within a week, it appears that individual experiences may vary, and ongoing use often leads to more significant long-term benefits.
Based on the available scientific literature, there is some evidence suggesting that certain supplements may have a role in managing bone pain, although results can vary depending on the specific treatment and population studied. For instance, one study highlighted improvements in pain scores among osteomalacia patients receiving supportive treatment with calcium, phosphate, and active Vitamin D [1]. However, it noted that the exact contribution of calcium to pain relief could not be definitively established due to the combination of treatments involved.
Additionally, magnesium has been linked with potential benefits in bone formation and pain relief. One study examined a magnesium-based framework that showed promise for delivering pain relief linked to osteoporosis [2]. Another study suggested that choline magnesium trisalicylate might help alleviate bone pain in patients with metastatic cancer, showing a significant pain reduction shortly after treatment [4]. Nonetheless, the need for further research is emphasized to fully confirm the effectiveness of these supplements in bone pain management.
Based on user reviews, many individuals have reported a range of improvements in their symptoms after taking the calcium and magnesium supplement. Users frequently mention significant relief from muscle and joint pain, with one reviewer noting that they experienced "elimination of muscle pain" and a "fast recovery after workouts" Read Review. Others have remarked on quick improvements in conditions such as heel pain and severe injuries, with one user stating their heel discomfort "almost disappeared" within two weeks of use Read Review.
In terms of long-term benefits, several users have shared positive experiences related to bone health, especially for those diagnosed with osteoporosis or incipient osteoporosis. For instance, one individual reported that after consistent use, their recent bone density test returned to normal, effectively lifting their previous diagnosis Read Review. Another user noted that after five months of taking the product, multiple pain symptoms had vanished entirely Read Review. While these anecdotal experiences suggest a trend toward improved bone and muscle health, it is essential to note that individual results may vary significantly from person to person.
Based on user reviews, many individuals have reported positive experiences when combining this calcium and magnesium supplement with other vitamins to enhance overall bone health. Users frequently recommend taking it alongside vitamins D3 and K2, believing that this combination aids in better absorption and effectiveness of the minerals for bone density and strength Read ReviewRead Review. One reviewer even emphasized that the blend not only facilitates calcium absorption but also contributes positively to overall health and bone quality, showcasing a comprehensive approach to managing bone-related concerns Read Review.
However, there were also testimonies regarding the use of this supplement on its own and its significant impact on alleviating bone pain and improving mobility Read Review. Users noted that their pain management strategies could effectively include this product without needing to rely heavily on medications, reflecting a preference for natural supplement combinations as a viable solution to their bone pain issues Read ReviewRead Review. Overall, combining this calcium and magnesium supplement with additional vitamins appears to be a popular choice among users for those seeking to improve bone health and manage pain effectively.
Based on user reviews, many individuals have found a calcium magnesium dosage of around 1000 mg to be effective for managing bone pain and related conditions. One user noted significant improvement after following their doctor's recommendation for a daily calcium dose of 1000 mg, reporting positive results in bone density after using the supplement regularly Read Review. Another review echoed similar sentiments, mentioning that the dosage was difficult to find in pharmacies, but once found, it led to noteworthy results, alleviating pain associated with osteoporosis Read Review.
Other users have experienced positive outcomes with differing dosages, where two tablets daily seemed to provide notable relief from pain in joints and bones Read Review. Overall, the consensus from users indicates that the right dose can lead to significant reductions in discomfort and improvements in overall bone health, particularly when combined with lifestyle changes like diet and exercise Read Review.
9
Heel pain reduced
6 people found this helpful
The heel pain has almost disappeared! I didn't initially associate this complex with my pain reduction, but after two weeks, my discomfort has diminished considerably, making it much easier to manage daily activities. I will order it again in citrate form next time!
9
Rapid pain cessation
4 people found this helpful
After suffering a severe leg injury while skiing, I was astonished by the rapid relief from pain after just one week of taking this calcium supplement. Although it may be coincidental, it has certainly brought me comfort. I also intend to try it on my elderly mother to assess its effects on her.
9
Reduces bone pain
I regularly take products for osteopenia and have been very pleased with the results. After five months of use, my shoulder and knee bone pain have vanished.
7.5
Pain relief achieved
7 people found this helpful
This effective drug has relieved irritability, improved my sleep, and eliminated muscle pain. I have experienced a fast recovery after workouts.
9
Improved bone density
1 people found this helpful
I ordered this complex for my mother, aged 65, who was diagnosed with incipient osteoporosis. The doctor recommended a daily calcium dose of 1000 mg, but such products were hard to find and costly. After taking this supplement intermittently, her next bone density test showed significant improvement, and the doctor lifted the previous diagnosis! This is definitely an effective product!
7.5
Noticed improvement
3 people found this helpful
Of high quality, this supplement is rich in content, addressing calcium deficiency effectively. As bones become brittle with age, I've observed improvement after taking the first pill. The blend positively affects the entire body, and I also combine it with vitamins D3 and K2 for better absorption. I highly recommend it!
7.5
Effective calcium source
2 people found this helpful
This product is of good quality, replenishing calcium deficiency for all ages. I've noticed improvements from the first pill, making it suitable for everyone. It positively impacts overall health, and I recommend taking it alongside vitamins D3 and K2 for enhanced absorption.
7.5
Boosts bone quality
1 people found this helpful
Excellent product! It contains 500 mg of phosphorus and magnesium, as well as up to 1000 mg of calcium, making it suitable for everyone. The large packaging of 360 capsules is advantageous as it reduces the need for frequent purchases. I have noticed an improvement in my bone quality. This supplement can effectively enhance osteoporosis management and prevent bone fractures from falls.
7.5
Pain relief experienced
3 people found this helpful
The Calcium Magnesium Complex has helped my sister significantly with her severe joint and bone issues. It relieves her pain effectively, enabling her to move more actively. We were advised by our doctor to take this complex, and we plan to continue using it.
9
Bone density improvement
2 people found this helpful
After being diagnosed with osteoporosis due to prolonged steroid use, managing my condition became essential. My doctor recommended a combination of calcium and magnesium alongside regular walking. I chose Country Life for its reputation, and I'm pleased with my results. My recent bone density test returned to normal. Following a fall, I was relieved my bones held strong due to this product!
10
Effective for osteoporosis
2 people found this helpful
Very effective product! I've been using this complex for quite a while on my doctor's recommendation for calcium at a dosage of 1000 mg. It's challenging to find a good supplement with such a dosage in pharmacies. My tests indicated almost osteoporosis of the bones, but after taking it for some time, a densitometry analysis showed improvement, and the diagnosis was completely revoked. This product certainly works; I highly recommend it!
9
Reduced joint pain
3 people found this helpful
Since winter, I've dealt with pain in my elbows and wrists. Prescribed osteoarthritis medication lowered my hemoglobin levels, but I opted for this complex instead. After a week of taking two tablets daily, I felt the difference—I could carry bags and clean with ease again. I also give this to my 10-year-old, but I wish the pills were smaller!
8
Calcium's role in bone pain unclear
In-depth clinical characterization of intravenous iron infusion-induced hypophosphatemic osteomalacia and its resolution.
We explored the impact of calcium treatment on bone pain in patients who developed osteomalacia, a condition linked to intravenous iron infusions. Our focus was on a group of 13 patients diagnosed with this condition, who experienced low phosphate levels due to excess fibroblast growth factor 23 (iFGF23) after receiving ferric carboxymaltose (FCM) infusions.
After halting the FCM infusions, these patients were given supportive treatment, which included phosphate, calcium, and active Vitamin D supplementation. We observed improvements in biochemical markers, including increased phosphate levels and reduced pain scores. However, it’s important to note that while calcium was part of the treatment regimen, we could not isolate its specific effects on bone pain from the other supportive measures used.
Ultimately, our findings highlight the importance of monitoring phosphate levels in patients receiving FCM, and stopping these infusions effectively addresses phosphate wasting. Although supportive treatment showed improvements in pain and bone density, the direct impact of calcium on bone pain remains unclear given the combination of treatments involved.
7
Promising drug delivery for osteoporosis
Synthesis and characterization of novel denosumab/magnesium-based metal organic frameworks nanocomposite prepared by ultrasonic route as drug delivery system for the treatment of osteoporosis.
We developed a novel drug delivery system combining denosumab and magnesium within metal-organic frameworks to target osteoarthritis. The framework showed good potential for loaded drug release, delivering about 72% of denosumab in just 8 hours.
Additionally, it released magnesium ions, which are beneficial for bone formation. Our cytotoxicity tests demonstrated that the system is biocompatible and encourages cell growth over time. While our findings are promising for pain relief linked to osteoporosis, further studies are needed to confirm effectiveness in real-world scenarios.
7
CMT shows potential for pain relief
The efficacy of choline magnesium trisalicylate (CMT) in the management of metastatic bone pain: a pilot study.
We investigated how choline magnesium trisalicylate (CMT) helps alleviate bone pain in patients with metastatic cancer. In a carefully designed study involving 26 participants, we compared CMT against a placebo in a crossover format, measuring pain relief at multiple intervals after dosing.
While we observed a significant reduction in pain just one hour post-treatment with CMT, other comparisons showed improvements that didn't reach statistical significance. This suggested that CMT might assist in managing bone pain, potentially complementing traditional opioids, but overall effectiveness is still under exploration.
References
von Brackel FN, Grambeck J, Barvencik F, Amling M, Oheim R. In-depth clinical characterization of intravenous iron infusion-induced hypophosphatemic osteomalacia and its resolution. JBMR Plus. 2024;8:ziae139. 10.1093/jbmrpl/ziae139
Alsaikhan F, Mahmoud MZ, Suliman M. Synthesis and characterization of novel denosumab/magnesium-based metal organic frameworks nanocomposite prepared by ultrasonic route as drug delivery system for the treatment of osteoporosis. Front Bioeng Biotechnol. 2023;11:1153969. 10.3389/fbioe.2023.1153969
Jakubowska-Pietkiewicz E, Chlebna-Sokół D. New trends in the treatment of osteogenesis imperfecta type III - own experience. Ortop Traumatol Rehabil. 2008;10:593.
Johnson JR, Miller AJ. The efficacy of choline magnesium trisalicylate (CMT) in the management of metastatic bone pain: a pilot study. Palliat Med. 1994;8:129.